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Department of Biomedicine - Forsk. & udd., Skou-bygningen - Faculty: Health

Postdoc in Immunology of Viral Infections

Deadline 30 Jan 23:59 CET

Expected start 1 Apr

  • Department of Biomedicine - Forsk. & udd., Skou-bygningen Høegh-Guldbergs Gade 10 8000 Aarhus C

  • Fixed term full-time position 1 Apr 2023 - 30 Nov 2025 ID: 11010

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The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of Immunology of Viral Infections as per 1 April 2023 or as soon as possible thereafter. The position is a fixed-term full-time position.

The department of Biomedicine prioritises diversity and a good work environment, as this is a prerequisite for groundbreaking research. In a dynamic and international research environment, dedicated employees are looking to generate new knowledge within biomedical research areas such as infection and inflammation, membranes, neuroscience and personalised medicine. The Department of Biomedicine provides research-based teaching of the highest quality and is responsible for a large part of the medical degree programme. Academic staff contribute to the teaching. English is the preferred language in the laboratory, at meetings and at seminars. The department employs approx. 500 people from all over the world, and they make use of the department's modern laboratory-, core- and animal facilities. The Department of Biomedicine focuses on innovation, entrepreneurship and collaboration with business and industry, and numerous researchers from the department have established companies to develop new medicinal treatments founded in strong scientific basic research. You can read more about the department here and about the faculty here.

About the research project

Understanding how the immune system fights viruses represents one of the main challenges in modern-day science. At the Center for Immunology of Viral infections (CiViA), we study the first line of defense against viral infections, with the goal of describing hitherto unrecognized layers of the immune system and novel mechanisms mediating anti-viral defense. In this project, we will exploit genome-wide CRISPR screening technologies to identify genes affecting initiation and termination of interferon production as well as genes that directly interfere with and restrict such responses. One main objective is to identify and describe genes restricting immune signaling driven by pattern recognition receptors. The project involves further development of screening technologies and immune-based readouts in model cell lines. As one direction, we will be studying multicolor fluorescence-activated cell sorting in genome-wide screens for improved dissection of homeostasis-guarding signaling circuits in the first line of viral defense. Also, we will be adapting CRISPR screens in efforts directed at characterizing the role of noncoding RNA networks in regulating cellular responses to virus infection.

Your job responsibilities

As Postdoc in Immunology of Viral Infections your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.
Your main tasks will consist of:
  • Performing independent research of high international quality, including publication.
  • Developing of reporter systems for detection of cellular readouts.
  • Performing genome-wide CRISPR screens based on an established pipeline, involving library design and production, handling of libraries in bacteria, production of Cas9-expressing reporter cell lines, lentiviral vector production, evaluation of transfer efficacy, next-generation sequencing, and bioinformatic analysis of NGS data.
  • Carrying out in-depth functional studies of gene sets identified by screening.
  • Supervising CiViA colleagues on CRISPR screen technologies.
  • Building research relationships within CiViA.
  • Managing an Aarhus University focus group on genome-wide screening approaches.
  • Contributing to teaching in genetics of medical students and students in molecular medicine
You will report to Professor Jacob Giehm Mikkelsen

Your competences

You have academic qualifications at PhD level, preferably within genetics and immunology. You are expected to have up-to-date knowledge on and hands-on experience with immunology and cell biology including CRISPR technologies. Documented expertise with cutting-edge methods of relevance for the project, preferably including library screens, is essential. In addition, you are expected to be able to lead all aspects of the project, including cell work and CRISPR screens, functional characterization, and validation of biological importance. It is essential, therefore, that you are interested in developing and performing CRISPR screen programs to be implemented in your own research as well as in CiViA and that you have a profound interest to validate and further explore key genetic discoveries.
You will be working in an independent manner, and must have ambitions and skills to develop the project to the highest international level. The project bridges research activities in several research groups, and you are expected therefore to be able to participate actively across different research environments in our research center.

At the personal level, you are ambitious, take ownership and possess good communication and interpersonal skills. You are happy to help colleagues and students in the lab. We are looking for a candidate who can bridge the interests and build relationships within the research center and assist to an inclusive and respectful research environment. We expect you to be fluent in oral and written English.
In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

Shortlisting will be used.

Questions about the position

If you have any questions about the position, please contact Jacob Giehm Mikkelsen tel.: (+45) 2361 7253.

Your place of work will be the Department of Biomedicine, Høegh-Guldbergs Gade 10, DK-8000 Aarhus C, Denmark.

We expect to conduct interviews in week 8.

Terms of employment

Application

Your application must include the following:
  • Motivated application
  • Curriculum Vitae
  • Diploma
  • Template for applicant - postdoc
  • A list of publications
  • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
  • A maximum of five of the publications of greatest relevance to the job may be submitted (optional)
  • Strategic research plan can be uploaded (optional)
  • Coauthor statement(s) can be uploaded (optional)
  • References/recommendations can be uploaded separately in the e-recruitment system (optional)
We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

Aarhus University’s ambition is to be an attractive and inspiring workplace for all and to foster a culture in which each individual has opportunities to thrive, achieve and develop. We view equality and diversity as assets, and we welcome all applicants.

Letter of reference

If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.
Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.

International applicant?

Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.

Questions about the position?

Jacob Giehm Mikkelsen

Jacob Giehm Mikkelsen Professor, Department of Biomedicine - Forskning og uddannelse, Skou-bygningen +4523617253 giehm@biomed.au.dk

Apply

Deadline: Monday 30 Jan 2023 at 23:59 CET