Academic Positions

Six post doc positions in bioinformatics and cancer genomics at Department of Molecular Medicine, Aarhus University, Denmark 1019802

We seek motivated and independent candidates for post doc positions in bioinformatics, each funded for 24-36 months, available at Department of Clinical Medicine, Faculty of Health, Aarhus University and physically located at Department of Molecular Medicine (MOMA), Aarhus University. The positions are available from March 1st, 2019 or as soon as possible thereafter.

Work environment
MOMA offers a vibrant and unique interdisciplinary research environment with more than 20 years’ experience in genomics, transcriptomics, and translational cancer research. The department has close clinical ties and houses state-of-the-art laboratory facilities, comprehensive cancer biobanks and significant next-generation sequencing facilities with access to large HPC facility and extensive genomics data infrastructure developed in collaboration between Aarhus University and Aarhus University Hospital (https://moma.dk/).

The three bioinformatics research groups focus on human genetics, cancer genomics, and evolutionary processes. They have strong ties and dual affiliations with the Bioinformatics Research Centre (BiRC) at Aarhus University, where parts of the projects may be carried out. The research activities span from statistical modelling and methods development to experimental hypothesis evaluation and clinical translation. There are also close collaborations with the wet-lab and clinical groups at the department (https://moma.dk/bioinf-2)

The research projects
The six positions are associated with individual research projects and all concern analysis of large genomics data sets, as detailed below:

A & B) Two positions to explore cancer evolution and tumor development across cancer types through the use of bioinformatics and evolutionary biology methods, focusing on NGS-based data. Particular emphasis will be on integrating data on mutations, gene expression, copy number changes and germline SNPs to improve our understanding of the selective pressures that may act at different time points in the life history of cancer and how cancer cells develop drug resistance and immune evasion. The project also includes developing methods to track cancer evolution in vivo using liquid biopsies or imaging data, though previous experience in these fields is not required (24-36 months; contact Associate Professor Nicolai Juul Birkbak, e-mail: nbirkbak@clin.au.dk, for further information.)

C) Explore the mutation processes in cancer through informatic analysis of thousands of cancer genomes. Particular emphasis will be on characterising and understanding how repair deficiencies shape mutation patterns using a combination of public and local cancer genomics data sets, integrating both germline variants, somatic mutations, expression data, as well as layers of genomic annotations. Concrete hypotheses may be sought validated in local patient cohorts or in wet-lab experiments through ongoing local collaborations. The project includes large-scale data analysis and potentially methods development, depending on interests. (24-36 months; contact Professor Jakob Skou Pedersen, e-mail: jakob.skou@clin.au.dk, for further information.)

D) Explore the effect of non-coding RNAs (ncRNAs) and RNA binding proteins on post-transcriptional regulation in cancer using expression data from tens of thousands of cancer patients. The emphasis will be on collaborative application and extension of locally developed statistical methods for motif-coupled-expression analysis to identify factors that appear to affect gene expression and evaluate their potential to drive cancer development using both local and public data sets. (24 months; contact Professor Jakob Skou Pedersen, e-mail: jakob.skou@clin.au.dk, for further information.)

E) Explore and characterise the landscape of intronic RNAs through analysis of more than one thousand, primarily locally generated, total RNAseq data sets. Non-coding RNAs derived from introns have received much less attention than intergenic ncRNAs. The aims will be on identification and characterization of functional candidates through integration with multiple layers of annotations, motif-coupled-expression analysis, etc.. Functional hypotheses may be experimentally evaluated through a local collaboration. Special emphasis will be placed on intronic RNA candidates that appear to be involved in cancer. (24-36 months; contact Professor Jakob Skou Pedersen, e-mail: jakob.skou@clin.au.dk, for further information.)

F) Explore the mutation processes in humans and related species by analyzing de novo mutations from whole-genome sequencing of parent-offspring trios. This can also include assessing the influence of de novo mutations on human diseases. Depending on your interests, focus can be on methods development, large-scale data analysis, or both. (24 months; contact Associate Professor Søren Besenbacher, e-mail: besenbacher@clin.au.dk, for further information.)

You must indicate which positions you would like to be considered for.

Qualifications
You must hold a PhD in bioinformatics, statistics, computer science or a related discipline. You should further have the following skills:

Proficiency in statistical data analysis and scientific computing, preferably with fluency
   in R or Python
Experience with HPC environments
Experience with handling and analysing NGS-based data
Fluency in written and spoken English
A strong scientific track record
Collaborative attitude

Experience with the biological systems in question is preferrable, but not a must.

International applicant
If you are an international applicant, Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please read more here: http://ias.au.dk/au_relocation-service/.

Salary is paid according to the AC collective agreement. The yearly basic salary ranges from 474.492,85 DKK to 499.578,02 DKK (incl. 17% pension) for post doc candidates at Health with three to eight years of work experience after their MSc degree. Supplements may potentially be negotiated dependent on qualifications. Please find more information in the Salary agreement catalogue for staff at Health. For further questions about salary level of post docs, please contact Professor Jakob Skou Pedersen, HR clin.hr@au.dk or International Academic Staff (IAS).

As an international employee you may be eligible for the researcher tax scheme. You can read more about the conditions you must fulfil to be eligible for the researcher taxation scheme here.

Aarhus University is a top-100 university with more than 40,000 students and 11,000 staff. Aarhus is a livable student city located at the sea, flanked by forests and beaches, and increasingly recognised for its range of attractions (https://goo.gl/CS5Baf and https://goo.gl/RKyEUi).

Required qualifications

Appointment as a postdoc requires academic qualifications at PhD level.

Formalities and references

  • Further information on the appointment procedure can be found in the Ministerial Order on the Appointment of Academic Staff at Universities.
  • The appointment is in accordance with the Danish Confederation of Professional Associations (Akademikerne).
  • Remuneration is in accordance with the above, and the Salary agreement catalogue for staff at Health.
  • Further information on qualification requirements and job description can be found in the Memorandum on Job Structure for Academic Staff at Danish Universities (in Danish).
  • Application

    Applications must be accompanied by a CV, diploma, a list of publications as well as a teaching portfolio. Template for applicant - postdoc must be completed and uploaded under Other information to consider. A maximum of five of the publications of greatest relevance to the job must be submitted.

    Further information on the application and supplementary materials may be found in the facultys Guidelines for applicants for academic positions and Aarhus Universitys Guidelines on the use of teaching portfolios.

    The assessment committee may decide to include non-submitted material in its assessment. In such cases, the applicant will be informed and obliged to submit material, unless the application is withdrawn.

    Applications submitted through channels other than the online application form below or applications which are not received by the application deadline will not be considered.

    All interested candidates are encouraged to apply, regardless of their personal background.

    Please apply here

    Deadline

    All applications must be made online and received by:

    14.01.2019
    Please apply online here

    International applicant?

    Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.



    Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 39,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 884 million Learn more at www.au.dk/en.